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KMID : 0364020080410020223
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Korean Journal of Thoracic and Cardiovascular Surgery
2008 Volume.41 No. 2 p.223 ~ p.228
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Serum Lmmunoglobulin G and M Level after Xenograft Valve or Valved Conduit Implantation
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Kwak Jae-Gun
Yoo Jae-Suk
Yoon Sun-Hee
Kim Woong-Han
Kim Kyung-Hwan
Kim Yong-Jin
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Abstract
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Background : The aim of this study is to confirm that peripheral blood sampling for measuring of serum immunoglobulin can predict immunological changes after xenograft implantation.
Materials & Methods : Between March 2006 and January 2007, 19 patients were enrolled (10 xenograft implantation group, 9 control group). Through 3 peripheral blood samples, we measured changes in serum immunoglobulin G and M levels preoperatively, and 2 and 10 days postoperatively.
Results : In both groups, serum immunoglobulin levels showed similar changes-they decreased 2 days postoperatively, then increased up to the baseline levels 10 days postoperatively. However, this postoperative change of immunoglobulin G and M was not significantly different in absolute value or pattern between the 2 groups (Ig G; p-value=0.393, Ig M; p-value=0.193).
Conclusion : We could not predict immunological changes after xenograft implantation by measuring serum immunoglobulin levels by simple blood sampling. Direct checking of ?-Galactose antibody may confirm an immunological reaction after xenograft implantation.
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KEYWORD
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Xenograft, Immune response, Heart valve prosthesis, Conduits
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